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KMID : 0895820110210020159
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Journal of Oriental Rehabilitation Medicine
2011 Volume.21 No. 2 p.159 ~ p.170
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Analgesic Effects of the Combination of Aconitum Ciliare Tuber with Honey in the Rat Models of Peripheral Neuropathic Pain
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Jo Hee-Guen
Park Ae-Ryon
Choi Jin-Bong
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Abstract
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Objectives: We have studied to know analgesic effects of the combination of Aconitum Cilliare Tuber with honey in the rat models of peripheral neuropathic pain.
Methods: Neuropathic pain model was made by ligating left 5th lumbar spinal nerve. After 3 days, combination of Aconitum Ciliare Tuber and honey extract was administrated each alternate day. Administration was divided three groups, that is NP-OA1(0.06 mg/ml), NP-OA2(0.24 mg/ml), and NP-OA3(0.96 mg/ml). After that, we examined the with drawl response of neuropathic rats legs by von Frey filament and acetone stimulation. And also we examined c-Fos, glutamic oxaloacetic transaminase(GOT), glutamate-pyruvate transaminase(GPT) and change of weight.
Results: Mechanical allodynia in NP-OA1 groups were significantly decreased compared with the control group. Cold allodynia in all experimental groups were no significant differences with the control group. c-Fos protein expression on the central grey, all experimental groups were lower than that of control groups. But, there were no statistically significant differences. Change of weight in all experimental groups were significantly increased compare with the control group. In blood serum GOT in NP-OA1, NP-OA2 groups were significantly decreased compare with the control group. In blood serum GPT in all experimental groups were no significant difference with the control group.
Conclusions: We had noticed that the combination of Aconitum Ciliare Tuber and honey decreased mechanical allodynia in the model of neuropathic pain compared with the control group and it has not efficacy in elevation of GOT, GPT and weight loss etc., the element of which becomes damage to liver. This study can be proposed that Aconitum Ciliare with Honey may be applicable to neuropathic pain in clinic. But it is reliability not that cold allodynia and c-Fos expression have effectively to control pain. Therefore we have to follow up about that.
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KEYWORD
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Aconitum Ciliare Tuber, c-Fos protein, Neuropathic pain, Analgesic effect
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